Neural, microvascular, glial and axonal structures are frequently affected in perinatal brain damage. It is therefore crucial to recognize them in advance in the child's unaltered brains. The first part of the presentation will be dedicated to the neuroanatomy of these structures in non-altered brains of the newborn child. Once the 'non-altered' neuroanatomy of the brain is established, we can evaluate the evolutionary neuropathology of perinatal brain damage. The second part of the presentation will present examples of neuronal, microvascular and glial alterations in damaged brain. Finally, we propose that these neuropathological alterations are evolutionary in children who survived the brain damage and that can play a crucial role in the pathogenesis of epilepsy secondary to perinatal brain damage.
Dr. Marin-Padilla is a professor of pathology at the Medical School, and specializes in pediatric pathology. A native of Jumilla, Murcia, Spain, he received his medical degree from the Granada University School of Medicine in 1955 and emigrated to America the following year. He served an internship at St. Francis Hospital in Jersey City, New Jersey, and then began his career in pathology as a resident at Robert Packer Hospital in Sayre, Pennsylvania. He spent two years as a resident at the Mallory Institute of Pathology in Boston, and joined the faculty at Dartmouth as an instructor in 1962.
As an internationally recognized authority on the brain, Dr. Marin Padilla has published extensively in his field and is an associate editor of the Journal für Hirnforschung, an international publication devoted to the neurological sciences. His present research activities are supported by a five-year grant from the National Institutes of Health.